Hdgf protein
WebAbstract. Hepatoma-derived growth factor (HDGF) is a growth factor related to normal development and tumorigenesis; however, the mechanism of its mitogenic and angiogenic activity still remains unknown. Analysis of the HDGF interactome could be important for … WebDOI: 10.1016/j.urolonc.2016.05.027 Abstract Hepatoma-derived growth factor (HDGF) is a heparin-binding growth factor, which has previously been shown to be expressed in a variety of cancers. HDGF overexpression has also previously been correlated with a poor …
Hdgf protein
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WebJul 13, 2024 · Although HDGF has been identified as a growth factor, its receptor on the cell membrane remains unclear. Nucleolin has been identified and validated as a HDGF-interacting membrane protein. As a result, HDGF activates the downstream PI3K/AKT signaling pathway by binding to nucleolin (Chen et al., 2015a). The consensus sequence …
WebHeparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the … WebJul 11, 2006 · HDGF protein expression was increased in the spinal cord of Tg mice. To investigate the protein expression level of HDGF in Tg mice, we generated antibodies against human and rat C-terminal sequences. In parallel, we made recombinant mouse HDGF to test the specificity of these antibodies. HDGF was cleaved from GST-HDGF …
WebJun 9, 2024 · In this study, hepatoma-derived growth factor (HDGF) was identified as a protein present in extracellular vesicles (EVs) released from human MM cell lines (HMCLs). Investigation of the role of HDGF in MM cell biology revealed lower proliferation of … WebThe deduced 669-amino acid protein has a calculated molecular mass of 74.3 kD. Hrp2 has a significant number of charged residues and is rich in prolines and serines. Hrp2 also shares an approximately 98-residue N-terminal domain with HDGF and mouse Hrp1 (Hdgfl1). Northern blot analysis of 8 mouse tissues detected highest expression of a …
WebThe encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. ... Full length human recombinant protein of human HDGF(NP_004485) produced ...
WebMar 21, 2024 · HDGF (Heparin Binding Growth Factor) is a Protein Coding gene. Diseases associated with HDGF include Lung Cancer and Hepatocellular Carcinoma . Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway . KRT1 (Keratin 1) is a Protein Coding gene. Diseases associated with KRT1 include … MSH6 (MutS Homolog 6) is a Protein Coding gene. Diseases associated with … LMNA (Lamin A/C) is a Protein Coding gene. Diseases associated with LMNA … Complete information for C7orf50 gene (Protein Coding), Chromosome 7 Open … JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a … NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. … YY1 (YY1 Transcription Factor) is a Protein Coding gene. Diseases associated with … askari leasing limited karachiWebJul 2, 2014 · HDGF is an acidic heparin-binding protein that was originally purified from media conditioned with the HuH7 human hepatoma cell line . It is highly expressed in fetal tissues and may be involved in the development of organs, including cardiovascular, liver, and kidney development [ 6 – 8 ]. atasdaWebNov 11, 2024 · Our data have shown that exogenous HDGF protein not only stimulated the phosphorylation levels of AKT and IκB but also increased the protein levels of the transcriptional factors HIF-1α and NF-κB p65 in oral cancer cells. The Western blotting results (Fig. 3) showed HDGF in a dose of 10 ng/ml was able to enhance more than two … askari longanecker npiWebNov 25, 2024 · To investigate the effect of HDGF on the two canonical pathways in ES, we detected the phosphorylation status and total protein levels of several critical kinases in control RD-ES/WT and RD-ES ... askari lion guardWebAug 10, 2024 · RXRα negatively modulates HDGF. To explore the upstream gene of HDGF, we assessed the transcriptional factors in the JASPAR database. Then, RXRα was selected as one of the most potential candidates that bind to HDGF promoter (Fig. 3A). It was revealed that RXRα knockdown upregulated HDGF mRNA (Fig. 3B) and protein (Fig. … askari lodge menuWebHowever, protein expression analysis showed that HDGF caused a marked increase in the cleavage product of caspases −3 and −9. These proteins are among the activators and effectors of the apoptosis process, and an increase in their expression is a hallmark of … askari lion king deathWebThis gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-bindi ng activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many … atascosa yamaha