Lxr gene card
WebLXRs bind to the promoters of specific target genes as heterodimers with the retinoid X receptor (RXR; NR2B1). The sequence elements identified by the LXRs are direct repeat … WebMar 19, 2015 · LXRs and LXR ligands have tissue-specific functions and mechanisms, and the heterogeneity of the different types of cancers and the emerging mechanistic …
Lxr gene card
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WebLiver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity Expression of some LXR-dependent genes is related to breast tumor … WebLiver X Receptor. LXR is a sterol sensor that promotes lipogenesis, whereas PPARα controls a variety of genes in several pathways of lipid metabolism. ... Scd1 is eliminated …
WebHow to solve problems with LXR files. Associate the LXR file extension with the correct application. On : Windows: Right click on any LXR file and then click "Open with" > … WebDec 3, 2007 · Liver X receptors (LXRs) alpha and ss belong to a family of nuclear receptors which form heterodimers with the retinoid X receptor and, upon ligand binding, stimulate the expression of target genes. LXRs were initially described as orphan receptors and oxidized cholesterol derivatives (oxysterols) were later identified as their natural ligands.
WebMar 21, 2024 · Tocris Summary for NR1H2 Gene. Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor … FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with … AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, … PPARGC1A (PPARG Coactivator 1 Alpha) is a Protein Coding gene. Diseases … NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) is a Protein Coding … KMT2C (Lysine Methyltransferase 2C) is a Protein Coding gene. Diseases … APOE (Apolipoprotein E) is a Protein Coding gene. Diseases associated with … CEBPB (CCAAT Enhancer Binding Protein Beta) is a Protein Coding gene. … ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. … NFKB1 (Nuclear Factor Kappa B Subunit 1) is a Protein Coding gene. Diseases … AKT2 (AKT Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases … WebLXR-RXR complex is linked to the responsive element LXR (LXRE) in DNA, a region of direct repetition 4 (DR4), recognized as the consensus sequence (5′-AGGTCA-NNNN …
WebFeb 2, 2024 · The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic metabolism. Many genes induced in response to pharmacologic LXR agonism have been defined; however, the transcriptional consequences of loss of LXR binding to its genomic targets are less well characterized.
WebFeb 1, 2024 · In contrast, a single LXR-like sequence was identified in the genome and transcriptome datasets of the Japanese lamprey, Lethenteron japonicum. Searches to the genome assembly and transcriptomes of the sea lamprey, Petromyzon marinus, allowed also the identification of a single LXR-like gene although too short for phylogenetic … government of canada emergency business loanWebJan 17, 2012 · The LXR/RXR is a so-called permissive heterodimer; in that it can be activated by ligands for either LXR or RXR. The heterodimer binding to LXR-responsive elements (LXREs) in DNA consists of direct repeats (DRs) of the core sequence AGGTCA separated by 4 nucleotides (DR-4). government of canada employee pension planWebJun 7, 2013 · Liver X receptor (LXR) activation improves glucose homeostasis in obesity. This improvement, however, is associated with several side effects including hyperlipidemia and hepatic steatosis. Activation of peroxisome proliferator-activated receptor alpha (PPARα), on the other hand, increases fatty acid oxidation, leading to a reduction of … government of canada employee pension portalWebFeb 24, 2024 · Liver X Receptors (LXR) control cholesterol metabolism and exert anti-inflammatory actions but their contribution to human macrophage polarization remains … children of the world projectWebNational Center for Biotechnology Information government of canada employer account refundWebApr 28, 2024 · LXR (liver X receptor) deficiency in myeloid cells accelerates the progression of atherosclerosis by increasing monocyte entry, foam cell formation, and plaque inflammation. Bulk cell-RNA profiling of plaque myeloid cells showed an upregulation of inflammatory mediators including oxidative, chemokine, and chemotactic genes. government of canada employment lawWebLiver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). [5] children of the world orlando