Web胰岛素抵抗与 fat/cd36协同调节长链脂肪酸(lcfa)运输、氧化。 胰岛素抵抗减少脂肪酸氧化、增加肌肉血脂,线粒体含量减少可能降低骨骼肌LCFA氧化能力。 最新研究表明胰岛素抵抗肌肉中脂肪酸氧化和线粒体含量都增加,由于脂肪酸运输大幅度增加超过其氧化能力 ... WebOct 22, 2007 · Cardiac power in hearts from young and aged WT and CD36 KO mice perfused at normal (A) and high (E) workloads. Palmitate oxidation (B and F) and glucose oxidation (C and G) rates in hearts from young and aged WT and CD36 KO mice at normal (B and C) and high (F and G) workloads.
A Novel Function for Fatty Acid Translocase (FAT)/CD36
WebFeb 4, 2024 · In this study, we investigated the role of palmitate acid (PA) and its cellular receptor CD36 in the progression of GC. Methods: Immunohistochemical (IHC) staining … WebBACKGROUND. We reported that high-fat diet (HFD)-induced metabolic syndrome (MetS) exacerbates lipopolysaccharide (LPS)-stimulated periodontitis and palmitate, the major saturated fatty acid in the HFD, amplified LPS-stimulated gene expression in vitro.Since CD36 is a major receptor for fatty acids, we investigated periodontal CD36 expression in … how much to change tie rod ends
Mannose metabolism inhibition sensitizes acute myeloid …
WebMar 29, 2024 · Palmitate-Induced Cardiac Lipotoxicity Is Relieved by the Redox-Active Motif of SELENOT through Improving Mitochondrial Function and Regulating Metabolic State ... Immunofluorescence analysis indicated that PSELT also relieved the PA-dependent increase in CD36 expression, while in SELENOT-deficient cardiomyocytes, PA … WebCD36 Is Modified by Thioester-linked Palmitate After CD36-transfected 293 cells were incubated with [9,10- 3 H]palmitic acid for 1 h, an anti-CD36 immunoprecipitate of the cell lysate was analyzed by SDS-PAGE. An 88-kDa radiolabeled band was detected by fluorography ( Fig. 2 ), indicating that CD36 is palmitoylated. WebA powerful tool in the functional assessment of FAT/CD36 has been sulfo- N -succinimidyl esters of long chain fatty acids. Sulfo- N -succimidyl oleate (SSO) and sulfo- N -succimidyl oleate palmitate (SSP) specifically bind to the 88-kDa protein FAT/CD36 and arrest the LCFA transport into adipocytes ( 13 ), heart ( 14 ), and skeletal muscle ( 11 , how much to change the clutch